The problem of single mouse clicks becoming double mouse clicks is a fairly ancient one and is well described on the net, but I have yet to see a solution. I am now suffering from this ailment and it is ruining my workflow. I'm a Mac person, but Windows people report the problem too (Microsoft acknowledge it and offer a solution).
Here is my particular version of this problem: If I click on a file to select it, it will open as if I had double clicked it. This is maddening if you merely want to rename the file or drag it to a new location. This behaviour happens both in the Finder and in programs like Adobe Bridge. In Mail, if I delete a message, I run the risk of deleting the next message as well, as if I had clicked twice. If I click the mouse to select a text entry point in Mail, I select the whole word. The problem is inconsistent, but so frequent that it is a serious handicap.
Apparently the problem is limited to my MacPro running OS10.6.6. It does not appear to occur on my MacBook (also running 10.6.6). It is not mouse-dependent. I have three mice (two Logitech and one Wacom, two old, one brand new). All are cordless, and all share the symptoms. The Wacom mouse (part of the tablet package) has always had this problem. It draws its power from the tablet.
I have played with the mouse settings in System Preferences to no avail.
Any ideas?