There are a bunch of can't miss sites.
Hunting Island, South Carolina for beach photography. Beach erosion is exposing trees on the beach strand making extremely cool foregrounds for sunrise. There is a lighthouse and pier here too, dunes with sea oats, a great marsh and intracoastal waterway for sunsets, and wonderful subtropical forest scenics.
Great Smokies National Park and Blue Ridge parkway -- drive across the smokies and take the parkway from the Smokies to Asheville. Tons of wonderful opportunities from lush river gorges to jaw-dropping layered landscape scenes from the ridgetops
Lots more, but these locations will definitely not disappoint.