Your scanner is excellent, I have one too, and I get fine results from it. I mainly use SilverFast because it is a far more refined application in many respects, but you should be getting very usable results from Vuescan, much better than what you are showing here. The main thing you need to be really careful about is not clipping the histogram at either end of the scale. Once you have all the data in an image file unclipped, you have choices about how to handle it. As a first-round diagnostic procedure, use the so-called "raw" scanning option, which effectively just picks up all the information from the scanner without making any edits in the scanning application, save it to your hard-drive and open the image in Lightroom. Before you do this scan, make sure you have Vuescan's colour management set correctly with the right profile for a Kodachrome slide. Also, I recommend an ARGB(98) colour space, for safety, (funny things can happen in scans with ProPhoto), turn off multi-exposure if the raw option doesn't turn it off automatically, and save in the TIFF file format, not JPEG. Once you open that scan in LR, the histogram should not be clipped, and if anything the image could perhaps look a bit dull and flat if all your LR settings are set to zero and linear. That gives you a good base from which to build the image luminosity and colour the way you want it. Once you've tried all that, please let us know what you observe.