I live in sRGB. As a university staffer, my photos are distributed to a wide range of end users, the vast majority of whom would not know a color profile if it bit them on the leg. My NEC monitor is set to the sRGB color space so I can judge how an image will look on the web and in lab prints (the two most common uses, with web being by far the most common.)
However, I shoot everything in raw, and when working on a high-end offset print project, or when making my own prints for portfolio, etc., I often will go back to the original raw files and process them through a wide gamut space in 16 bits, etc.