Increases in the Luminance noise reduction and Detail sliders will allow me to make additional increases in the Amount slider; and thus improve image sharpness?
No...not exactly...fine tuning ALL of the Detail panel settings including; Amount, Radius, Detail, Edge Mask and having the correct Luminance Noise Reduction is the key to getting optimal image detail. If you add the correct luminance noise reduction you can increase the detail settings and amount of the sharpening but it all depends on the image, the source and the ISO. Unfortunately, there are no simple answers. It's really an image be image determination.
However, there is light at the end of the tunnel–once you get an image type optimized, the odds are pretty good that other images of the same type will respond equally well. That means you can create templates for the types of images you do and then only fine tune the image.
The other sliders; the Luminance Noise Reduction's Detail and Contrast and Color Noise Reduction and Detail are less worrisome unless you are using hyper ISO's.