Mark:
I once did a not very rigorous comparison of some Pentax 67, 645 and 35mm lenses on a Pentax DS (6 MP). I could see very little difference comparing the SMC M 50mm f/1.4 the 645 55mm f/2.8 and the 67 50mm f/4. The 645 might be the best of the group, but not by much. In most cases, I would say there is no advantage to using the 67 lenses unless you are using a Zoerk shift adapter to produce stitched photographs. The 67 lenses are bigger, heavier and slower than their 35mm counterparts. If you don’t have the 35mm lens, that’s a different story. I don’t have a 35mm or 645 300mm lens, but I do have a 67 300mm ED; it works great on the smaller formats.