The only handicap that I can foresee is that once adjusted for preference, the shot will have to remain as adjusted.
No tilt/swing effects on the fly, which I would think would be the most important aspect.
Even using shift, say you have a scene where you pan up on a building and want to make it appear really tall so you would want to start with shift and pan up while 'un-shifting' to have the building appear taller.
But sill a nice bit nice for still images!
you mean using something like thisgigapanbot