Steve, exactly. So, what to do if the situation demands f22? Well - as Doug said, and as I teach - you can't beat physics. So if you must shoot at f22, the only way to achieve higher net image quality is ... to stop worrying about pixel sizes (anything from 12 microns down is fine), and just use a larger area sensor. More mm^2. Something that the large format film guys have known for decades.
To ondebanks and Doug Peterson: if you need to use a high f-stop like f/22, it is almost certainly in order to get adequate DOF, and in that case, a larger format will not help one iota, due to the higher f-stop needed with a larger format to get that same DOF. The scaling rules have been discussed many times in these forums, and it goes like this:
- to make any use of the larger format, you need to produce a larger image on the larger sensor, by increasing focal length
- to get equal DOF and equal OOF effects when images are displayed at equal size, the f-stop must be increased in proportion to focal length (so each circle of confusion on the image at the focal plane is enlarged by the same factor as the image itself)
- this increases diffraction spot size by the same factor as the image size, and thus
- when images are displayed at equal size, diffraction and OOF effects are equal.
For equal subject distance, the effective aperture diameter (a.k.a. entrance pupil size) determines the degree of both diffraction and OOF/DOF effects relative to the size of the image of the subject itself. That is, effective aperture diameter determines the angular extent of diffraction and OOF blurring.