From DV, head west on 190. If the road is clear, and you've not pressed for time, you can take the Wildrose Canyon cutoff. It's paved, but kinda slow. It's also very pretty! Short dirt-road detours to Skidoo and the Charcoal Kilns are available if the roads are dry. Staying on 190 to Panamint Valley Road is quicker. Once you reach Panamint Valley, head south on 178 (Trona / Widlrose road) to Ridgecrest. Stay on 178 across Walker Pass. If Walker is closed, or you're averse to curvy roads, take 395 and 58 to B-field. This is further, but much faster. In terms of time, they are roughly equal. Avoid 178 on holidays or weekends! Much of the road is is two lane, and it will be clogged with RVs.
Leaving Lake Isabella, you have two roughly equal choices.
Take 155 to Delano and Highway 99, or stay on 178 all the way to Bakersfield. 155 is slow and snarly, but shorter and very pretty when you drop down into the foothills. (Don't try the Jack Ranch Road shortcut to Fountain Springs unless you've got plenty of time - the road is VERY slow.)
178 to Bakersfield is a fairly quick drive, but is (once again) a little longer.
North on 99 to Fresno, then 41 to Yos.
Or stay on 99 to the Madera area, and take the quicker 140 east. If you're headed directly for the valley floor, this route might be fractionally faster.
IMO, I don't suggest the Northern Route, via Tahoe. The roads entering Yos from that direction tend to pass through lots of small towns and can suck up time like crazy.
No matter which route you take, total driving time from DV (Furnace Creek) to Yosemite will be "All day." I'd guess 10 hours at the least. There are plenty of things to see along the way, maybe you could camp near Isabella (there's a nice free site just W. of Walker Pass) and make it a leisurely two day drive?
From Yos to Big Sur. West on 140, drop down to 152. I don't know the best way to get through the Monterey/Carmel area. Expect plenty of traffic. Taking Laureles Grade road from 168 (at Laguna Seca Raceway) to Carmel Valley Rd., then west to 1 may be the best. (??)