I find that when I do a one step downsize to websize, that Photoshop creates softer images and sometimes aliased diagonals, a big deal since I shoot architecture.
I have created two Photoshop actions that downsize my P65+ Tiffs in 10% steps (one for horizontals, one for verticals). This has provided me with the best quality for web portfolio. I then duped the actions and threw out the bottom half of the steps which left me with a nice print size. All this makes it easy to put multiple size files on a disc (which clients appreciate)
From there, sharpening is up to you, and of course sRGB.
Best,
CB
First Image is one step downsize, second is incremental (better sharpness and contrast... neither was sharpened)