You want raid 1 for your boot drive if for no other reason than it's a total PITA to restore and rebuild a drive/OS.
1 - each drive needs to be on its own channel. Built-in RAID on most motherboards fights with itself for I/O otherwise. That's simple enough, though, as most boards have two connectors for just that. 3 or more really requires its own controller card, which is a whole other issue. But we're not talking about that now, so it's simple. 2 drives and 2 channels. This gives you good fast access - same write as your normal drive but 2x the speed or better for reading.(latency goes down to raid 0 levels for reading but not writing)
2 - You need a swap drive. This can be a physical ram disk of 2-8GB or a SSD. Toss your swap file and your temp directories on it. This also needs to be on a completely different controller from the RAID array so that they don't fight each other. Most motherboards, though, have major issues with raid and non-raid at the same time, so you need to do a little research here. Since this isn't a boot drive, you can also get by with an ATA interface or a cheap controller card. Once you have it sorted out, just having the swap file and virtual memory/temp spaces/etc all NOT clogging up your boot drive is a good 2-3X speed increase.
Even doing this with an old crappy hard drive is a noticeable improvement. Or just setting aside 1GB memory as a soft ramdisk(as opposed to a hard one like a ram-drive) can be enough. Windows 7 makes this easy as well, so a 3/1 GIG setup is not a huge headache to accomplish. (since the maximum for a 32 bit process is 2GB normally, it's a good way to speed up things for often no more than the cost of the ramdisk software.
Again, this may mean 4 drives - 2 OS(array), a swap, and a large storage drive. Some motherboards are not truly capable of handling four different drives at once. Mine, for instance, won't, which is why my large storage drive is external. (though it does handle the main raid 1 and the swap fine, more gives it a headache)
3 - The RAID need to be RAID-compatible drives. WD for instance, makes drives that are made to work better with cheap on-board RAID controllers. They drop out of the array less often as a result. You can of course run these just fine as single drives. And any dedicated RAID card will also work fine with normal or RAID type drives, but those that are bootable and reliable can run a couple of hundred dollars. Now, they are worth every penny, but most people can't afford them for home use.