Hi Edmund,
Would this be your problem, you might have taken your first photo and it is sharp, but then you are unable to get the second or third photo as sharp as the first, even though you might focus multiple times.
I have something that might help, simple to do, does not take much time.
I am assuming that since you have a Leaf back, you are using Leaf Capture 11. In my set up of LC11, I have a small 100% window in the bottom left.
Set up and do a groundglass focus and take an exposure(the exposure is correct) check the focus in the 100% window. If it is not as sharp as you think it should be, do the following. Do NOT open the lens or refocus using the groundglass. Simply take your focusing knob on whatever standard you use and make a micro-adjustment, either forward or back, the standard should just barely move(I have a sinar p and do not have to lock focusing knobs ever). Advance the shutter and take a second exposure, watch the 100% window and as soon as the 2nd exposure has processed, it should be sharper or a little more out of focus. If it is sharper, you have probably hit the focus and another micro-adjustment in the same direction may not increase the focus. If the 2nd exposure is softer, you probably chose the wrong direction. Simple make two micro-adjustments in the opposite direction and take a 3rd exposure. Check the 100% window and hopefully it is sharper than the first exposure. If the first exposure is the sharpest, it might simply be your lens.
I use a 150mm Apo-Sironar(a film lens) on a sinar p, with a leaf valeo 17wi to photograph jewelry, so that the jewelry is reproduced at lifesize(100%) or larger on the page. I use this all the time to fine tune the focus on diamond rings, etc.
This is a way to refine your focus and achieve critical focus, it is very difficult to use if your focus is way off.
I hope this is clear and understandable.
Good luck,
Brian Woolf