Can't get close enough? Then you need a smaller format! (Fortunately, cropping counts as a smaller format, so long as your photosites are small enough to sustain the crop.)
C'mon, BJL. Get real! Whilst I'm sympathetic to the idea that the smaller format can compensate to some extent for it's lower performance regarding noise, DR, tonal range etc through use of a lower ISO setting, in conjunction with a wider aperture, to provide a shutter speed and DoF equal to that of the larger format, you seem to be forgetting that a 12mp image through a 400mm lens cannot compete with a 15mp image through a 640mm lens. The differences are huge. In fact, the differences would be more significant than the differences between a 400mm lens on the 12.7mp 5D and the same lens on the 50D, because at least the 5D has a noise, DR and tonal-range advantage over both the 50D and equivalent 4/3rds format, say the E-30.
In other words, I would rather use the 100-400 IS on a 5D than the Zuiko 50-200 on the E-30. You're better at maths than I am, but according to my calculations, a 12mp E-3 image taken with a 200mm lens, cropped to the same FoV as the 50D with 400mm lens, would result in approximately a 5mp image for the E-30, or even less depending on aspect ratio.
How can you compare a 5mp image with a 15mp image? As I said, get real!
I do not feel like doing all the calculations, but the rough guideline is still that the 50-200/2.8-3.5 achieves a given shutter speed at about one stop lower sensitivity due to being able to use a lower f-stop, so 800 ISO works for me about like 1600 ISO works for you with the 100-400/4-5.6.
We've been through these calculations before. The one stop 'equivalence' difference between the 4/3rds and Canon APS-C formats is an exaggeration. It's more like 2/3rds of a stop, but let's not quibble. A more significant concern is the much lower DR of the E-30. On equal size prints, we're looking at almost a 2 stop difference in DR at high ISO.
Here's the DXOMark results showing that huge DR difference between the E-30 and the 50D on normalised prints.
[attachment=17490:DXOMark_50D_v_E_30.jpg]
So out of interest, how often is sensitivity of 1600 ISO not fast enough for you with wildlife, using that kit? Your example of f/8@400mm, 1600 ISO seems to become "f/3.5@200mm, ISO 500 and crop" for me. Maybe I would benefit from more pixels or a TC.
Frequently, especially when I don't have a tree to lean against. I ruined lots of shots some time ago when travelling along the Daintree river in a boat, due to inadequate high-ISO performance of my 40D. When you have to underexpose at ISO 3200 to get a fast shutter speed with an APS-C camera, then forget it. Also, wide apertures with a long telephoto lens have their disadvantage with regard to focussing accuracy. Not much point in getting the bird's beak sharp when you really wanted its eye sharp. Better still, get both its beak and eye sharp at F11.
The greatest upgrade to this 100-400 IS lens I've experienced was when Canon brought out the 20D and ISO 1600 was usable for the first time in my life. Teleconverters at best provide a very marginal improvement in my experience.