I am running a Unibody MBP 15" and a 24" LED ACD. I profile with Coloreyes Display Pro and a Spyder3. I have excellent screen to print matching from Photoshop or LR.
I notice that images exported from PS (CS4) or LR (v 2.5) appear different in Preview and other Mac system applications than they do in PS/LR. Generally, they are more saturated and shifted towards magenta. I have only begun noticing this in the past few months. It does not seem to be consistent with all images, primarily ones exported from PS/LR. If I untag a photo in PS, it will appear correctly in Preview, regardless of the actual color space.
You're right, I've noticed that too. I'm not sure why but I think that Preview might not be colorspace aware.