The Lowepro Pro Roller 1 lists for $289 at Amazon, B&H, etc. I’ve only used it a few times so it looks like new. Has a separate removable insert that is variable depending on type of equipment to be carried. Lowepro sells inserts so one could have inserts for DSLR and medium/large format. Fits most airplane overheads. Offers solid protection for the traveling photographer. Here’s Lowe’s description of the bag:
http://products.lowepro.com/product/Pro-Roller-1,1997,28.htm$175 with free US shipping
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