I have both types and I have to agree with the others here that I have not noticed any perceptible difference between the two when shooting with the 1DS mk3. Downloading may well be different, but when downloading from my 16gb Extreme 3, I just go and put the kettle on. Seems to have finished by the time the coffee is ready!
Regarding the two card slots. Ever since I have had the camera I have shot Raw to the CF, and fine jpeg to the SD. It seems to run quite quickly, but have not tried just the one slot to see if it speeds up.
Jim