After I got my new MacPro I started only processing my images at 16bit (before that I used that only when things were critical). Now file sizes are on average in between 2gb & 6gb per file. I quite often get Photoshop CS4 to refuse doing stuff because it thinks it hasn't gotten enough memory (12Gb in the machine). After closing PS and reopening I can continue. Quite frankly I find this a bit disappointing and begin to wondering whether it is me or the machine?
Huh??? Between 2 and 6 *Gig*s each on AVERAGE? One of my largest recent files is a pano assembled from 5 P45+ 16bit files, put into CS4 and has about 10 layers total added --- and it is only 2.6 Gig if saved as an uncompressed layered tiff! So I am wondering now about exactly what your typical image file is?
Regardless, I can confirm that 2.6G file when open in CS4 on my older Mac Pro with 24G ram runs fine, and OSX/CS4 is limited to 3G RAM max. If I do anything on it, it definitely has to tag the scratch disk, but it will and does and moves along just fine considering what it is...
*IF* you are getting memory errors from CS4, I suggest you try turning off Open GL and see if they go away. FWIW, turning Open GL off has solved both memory errors and display accuracy issues for several of my colleagues with fast, high RAM, high-end video card systems.
Edit: And of course make sure you have a scratch disk selected and enabled with a check in the preference box designating the drive. No scratch disk with files that large will most certainly have system problems.
PS: My average single file size from the P45+ in 16-Bit even after healthy manipulation in CS4 with layers retained and saved as an uncompressed tiff is maybe 400 or 500MB -- but I only process a few to that degree so the average will be even lower, and these files come out of the raw processor at over 230MB each. Obviously my Canon files are smaller still, lowering the average size further.