Is that lens really capable of resolving so much finer? The attached captures show the raw pixel view of a 5D2 and a G10 shot.
Interesting! I think it's clear that the 5D2 at F8 is doing a better job than the G10 at F5.6 in this comparison. One might argue whether or not the G10 lens is sharpest at F5.6 and whether or not the 35mm lens used with the 5D2 is sharpest at F8, but no matter. If one were to go up one stop with both cameras, the differences would probably be similar.
The major issue here is DoF. In order to produce images with approximately equal DoF, the F stop used should vary in proportion with the diagonal of the sensors, as a rough guide. If it doesn't, DoF differences will be very apparent in real-world scenes that have significant depth.
I'm reminded here of Michael's comparison of the G10 and P45+. As I recall, the G10 was used at F3.5 and the P45+ at F11 to take shots of the same forest scene from the same position. At A3+ print size, experienced photographers could not identify which camera had been used until they realised that one of the prints had a slightly shallower DoF and that was likely the print from the P45+.
The fact is, the diagonal of the G10 sensor is only 9.5mm. The diagonal of the P45 sensor is 60mm. To get the same DoF that the G10 produces at F3.5, the P45 should be used at F22 (60/9.5 x 3.5 = 22).
Similarly, to get the same DoF that the G10 produces at F5.6, the lens with a 5D2 would have to be set at F25. I think in these circumstances the G10 might produce the sharper result.
I think it's generally true that the larger format will always produce sharper results than the smaller format when the lenses for the different formats are use at their sharpest aperture. But the trade-off is less DoF for the larger format.