How were the custom profiles made? Were the targets printed through CS4 and Leopard?? Is the printer chosen as the default printer?
There is a problem with printing targets (and subsequent prints) from CS4 and Leopard for large format Epsons. Until the problem is addressed by whoever is responsible, as far as I can tell, the only solution if you're going to print through the Epson driver, is to print from CS3 when in Leopard.
In theory, there is a workaround where you open the ColorSync Utility and choose the same profile as the one you're printing to - which forces ColorSync into a null transform and bypassed the problem, but I haven't tested this yet and I'm not sure how you'd print a profile target anyway.
There was also a bug, and I'm not sure if it was ever addressed, where if your printer of choice was not the default printer in your printer setup, you would get a weird posterization on skin highlights.
I print all day to Epson 9800 and 9900 from Leopard and CS3 with no problems at all.
When I compared measurement files from the same Gretag target printed to the 9900 with Leopard and CS3 and CS4, there was up to a 20.72 Delta E difference with many patches in the 10-16 Delta E range. That's a huge difference.