I am running on it on Vista64 without issue. However, I did see a post on another forum where it would not run on Vista64 for them, so you are not alone.
Did you do anything special with setup or anything? I downloaded the trial version (thank god I didnt buy it yet) and did the whole setup etc. I start the application, and the DXO window comes up...and then it stops working and windows closes it. ANy idea?