A quick note: 4.6.1 has been released and I do *NOT* recommend you install it on an 8-core Mac Pro! Apparently there are some issues cropping up in that configuration. For me, the program hung endlessly or failed to render an image preview, or simply crashed. I ended up doing a complete uninstall of 4.6.1, and reverted to 4.6.
On the upside, I can confirm it does a superior job rendering P65+ files than 4.6 did, but it isn't stable enough yet to rely on.