I've used several Firelite Smartdisks with USB2 over the last several years, with good performance and no problems. I don't know if their latest capacities are in the 400-plus GB range yet. I did see small USB2 Toshiba drives at Best Buy, 400 GB or so, and I would have 100 percent confidence in those, since I work in Irvine where they put them together, and am familiar with their QC. I've also used Toshiba laptops since 1998 without a failure, a couple of them in constant use on Internet for 7-plus years. My previous Toshiba external drives were the PCMCIA 5 gb drives circa 2000, and again, heavy portable use with no problems.
Attached is a photo of some of my portable gear from a few years ago. I would have preferred even today to have PCMCIA drives in 500 GB capacities, but that's not going to happen apparently. Some of the new laptops don't even have PCMCIA slots now. Is that progress in portability, to replace a backup drive carried internally with one carried externally? Sure, the capacity is higher, but....