Let's be sure we are talking about the real issue here. All these loaders will load what ever the default system profile is, not some other profile. Also they do one thing and one thing only, load profiles, video luts and perhaps monitor luts at startup. They do not influence anything after that. But yes, you should only have one and it should be the one associates with the program you are actually going to use. LutLoader is from ColorEyes.
Well, for whatever it is worth, I cleaned out the startup folder and reprofiled with SpectraViewII. I shouldn't say this yet, but so far, no more blue screens of death from Windows.