I find running LR2.0 on my MacBookPro w/3GB RAM is a little pokey compared to v1.4.1. The seems to be a little hesitation getting the cursor back after using certain functions (crop, color corrections, and syncs). However, the new features are worth it. I'm sure that Adobe will upgrade with a fix. I'm currently returning from an Alaska vacation and I have a library containing only images from this trip which is up to about 3,000.
I only have about 10GB of space remaining on my 160GB internal drive. All images and library are backed up to a FW800 OWC 320GB external portable drive, but the main library and original images are on my internal drive. The drive being this full could be a contributing factor as I think Apple recommends at least 20% free HD space for optimum performance.
I don't notice the delays on my MacPro 8-core with 16GB RAM. I have 60k+ images in my LR 2 database.
These are the problems of living on the "bleeding edge" of technology.
Bud James