Not specific to DryZone, but to completely waterproof bags in general when used in wet climates:
Beware of moisture buildup inside the bag. They're as impervious to water getting out as to water getting in. It's a special issue if you open the bag outdoors in high humidity or even manage to dribble some water in, then come back indoors to air conditioning. Best strategy is to allow the bag to acclimate an hour or two to ambient indoors before opening it, then remove all the contents overnight and leave the bag open, toweling out any accumulated moisture before going to bed.
I.e, even if you keep water from seeping in, time and temperature changes can result in accumulation within the bag.