The only "natural" ISO speed of a sensor is the minimum value (maximum amount of exposure) that gives acceptable highlight headroom, which with the D300 seems to be about ISO 200. Special lower settings are akin to "overexposure and pull processing" with film, and sacrifice some dynamic range through greater risk of blown highlights. The ISO standard for base ISO speed of a sensor is akin to the lowest exposure index to which a film can be safely pulled, and has no direct relation to the ISO speed of a film, which is instead based on adequate shadow handling, rough to four stops below mid-tones.
DSLR sensors typically give four or more stops below mid-tones to ISO speeds well above their base ISO speed, with output shadow handling at low ISO speeds typically limited by standard JPEG conversion rather than noise in the raw output. So a DSLR sensor's "film-like" ISO speed limit is typically well above its base ISO speed.
As far as I know, it is not true that any one ISO speed setting involves "no amplification" or "unit amplification" with all higher settings involving "amplification" and all lower settings involving "attenuation". Instead there is a conversion from charge (in electrons) to the voltage that goes into the A/D convertor, with each different ISO setting having a different conversion factor in mV/e-. (I understand that the CMOS sensors in DLSRs do this charge-to-voltage conversion at each photosite; with CCD's it is done off the sensor itself.)
Since this conversion factor has physical units, there is no meaning to a value of "one" for a particular ISO speed. Instead, there is just a range of options in shadow noise levels and highlight headroom.