I've never really liked Lightroom's handling of sharpening or noise reduction that much, As such, I generally leave the default sharpening where it is, perhaps boosting "detail" ever so slightly, and use it as "capture sharpening". The reason being that Lightroom, for me, is only the first stop in image processing, not the last, so I prefer not to sharpen until the end.
As for noise (which I know you didn't ask), I'll set luminance to about 25 for just a degree of noise reduction. Like sharpening, I prefer to work in Photoshop.
The big plus with both Mark III's I've found is that skin tone are much smoother than before, and I have less "retouching" to do.