Not size but you DO need to factor in the image resolution and the media. Sharpening for an image at 240 will be different than an image at 360 or 480 PPI. Also, sharpening for a glossy print will need to be different than a matte paper print.
But the size of the print really is not a factor when determining sharpening.
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For commercial pay-for-print work, I use a professional large-format RIP which automatically resizes the input file to the required output size and resolution for the designated printer. The results are generally excellent, but I'm looking at PKS with a view to optimising the sharpening process with my own files. However, I'm somewhat confused as to what should be the correct resolution to select for the PKS output sharpening step. Should this be the resolution of the input file at the original size supplied to the RIP, or the resolution of the output file at its final size as processed by the RIP and sent to the printer, or is neither correct? I would have thought the former, if anything, but I'm not sure that either is actually correct for this workflow.
If Jeff or anyone else who knows PKS could offer any further advice or clarification, I would be very grateful.