I've made large prints from LR without problems. Your situation might have been a fluke. It is possible that Lightroom and/or your system does not have enough physical RAM to spool the job. But I doubt it.
Restart the computer, make sure no other programs are hogging RAM (especially Norton or MacAfee etc.), launch Lightroom and try again. Watch the print this time; if the problem happens again you can cancel the print job so you don't lose all that paper, ink and time.
You could also try printing that flat TIF file from Lightroom (instead of the layered file from round-tripping); a flattened file will be much smaller to spool.
I almost always print flat files.