2x superresolution does indeed find extra data. My assesment is that you don't really get an effective 2x bump, but you do get some extra. That, combined with the multi-shot noise reduction, is very appealing technologically, particularly for your purpose as I imagine.
Still, if the darn thing doesn't work, then there's probably not much you can do. The PhotoAcute developers seem more interested in bulk sales to P&S camera owners (where the "win" is even bigger) than in fringe high-resolution uses.
Speed is an issue, too. It takes a long, long time to run on 10mpx images. Get a cup of coffee long. You might be better served for time efficiency, as well as better scans without fiddling, to as Dustbak suggested "rent" a good quality scanner from eBay. They hold their value well, so depending on how well your sell-it-forward auction goes, you could break even on the use of it.
I'm not standing in your shoes, and it seems like you've tried a lot of options so far. I mostly am doing multi-shot stitched Repro work (very successful with this), which is a far cry from negative scanning.
Good luck!