If you are trying to creat the ICC profiles with the creatICC function of QTR
you should print the file (the 21 or 51) using the exact settings you will be using to print your pictures when you use the profile. So if you are going to be printing from QTR, then print the file from QTR. Apply the exact combination of curves you will use. Luster should be a good setting for the Fine Art Pearl. I don't know if you can get the 21 and 51 files on 1 A4 document, but I only use 1 or the other, not both. Typically I use the 21, but I have not compared the results, so I can't comment on the differences.
I do not use the 21X4 random file, so I'm no help there.
Hope this helps