That makes sense. I think it will be something I will need to revisit in a couple of years. I am also very interested in starting to do a lot of large pano's and the fill size ends up getting huge in a lot of cases, at least for the master Photoshop/TIFF file.
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I am using a SATAII RAID0 arrangement with a dual-opteron box (effectively 4 processor cores) with 8GB RAM and a vista x64 box.
The RAID0 is a bit risky, but quick. I do lots of large panos (typically 3GB PS file size) and yes, the load time is a bit slow, as are things like sharpening. I would suggest using RAID0 arrangements with faster disks (10k). Internal SCSI and SATA will usually beat attached storage, but not always, esp in some cases of processor contention.
re: processor utilization I find all the cores are utilized by CS3 during a processor-intensive task.
I would humbly suggest that the best use of your funds would actually be to build two identical machines, and use a KVM switch or multiple monitors to get them both working in parallel.
That way, you start a process, switch to another machine, then go back when you're idle again.
I have this setup, and it works very well.