I've come across a some consistently weird behavior which has effected my TIFF files from Canon RAW in LR.
I'll work with an image in LR and save it as a 16-bit TIFF, then open and edit more in PS. I often save incrementally when I'm working on an image with lots of layers and retouching. Eventually, I'll flatten and sharpen the image and covert to CMYK for publication.
Now here's the hitch. Sometimes, even if I do a "Save As. .", a new dialog won't open, it just saves the file. If I do a second "Save As. .", then I have the usual option to change to file name, and the parameters of the TIFF come up. Most of the time, the image will show ZIP compress (versus none or LZW), and the Per Channel Pixel Order is what I call "non-conventional". LR has created a the TIFF and saved it using "Per Channel -- RRGGBB" rather than "Interleaved - RGBRGB".
I usually catch this. However, one editorial went to publication recently and the printer had problems with two of the images RIP'ing properly. The images ended up being soft and slightly pixelated.
I opened the CMYK images, resaved them (my first tip off is that they would not render the thumbnails in Windows Explorer), and sure enough, the Pixel Order was out of whack and it showed ZIP compression on the file (not a layer ZIP compression). I'm convinced this was the root of the reproduction problem. I some how had not caught this when I saved my final work -- possibly under stress of trying to make FedEx for the deadline.
Why has Adobe foisted this on us as some sort of default saving of LR? I found this to be the case with the Beta and figured it was just a Beta-error. Saving a ZIP compressed TIFF and changing the Pixel order are, at this point, non-standard TIFF specifications. (In LR, when I export the TIFF, I specify "none" for compression.) These settings are fine if they are made as conscious decisions by a user for personal reasons (ZIP compressed files ARE smaller, especially because LZW for CMYK does not work -- makes the files even larger), but for pre-press, this is a disaster.
I know this is LR related because I've never encountered this when saving and working with 16-bit files from Capture One, Raw Shooter, Bibble or BreezeBrowser.