Is your lightroom library located somewhere within %username%\documents folder hierarchy? Vista, by default only gives standard (non-admin) users write permission there. You have two choices:
1) Run as admin - easy to do, the risks are *somewhat* mitigated by the fact that you are still protected by User Account Control, preventing a malicious process from starting or being installed, however, any allowed user processes are running at an elevated security level, not recommended. Even so, this is much better than running as Admin under XP.
2) Change permissions on the Drive/Folder you want to write to:
Start Menu | Computer
Right-Click desired Drive and or Folder | select Properties from the menu
Note that \\office\users do *not* have write permission, we'll change that
Click the Edit buttom - this will invoke the User Account Dialog, authenticating access.
Fill the Write Permission checkbox, then click apply
I'm been running Lightroom on Vista including Beta 4. Ver 1.0 does *not* appear to respect system user folder redirection *at all*. As a Windows GDI programmer since 1992, I find this incomprehensible since clear guidelines regarding handling User and Computer profiles have been in place since 1996 (NT 4.0)!!
Let me explain: On my home machine, I have two physical drives, with a standard install of Vista on the 1st "C:". Following best practices, I have my personal account (non-admin), john.murray. This results in systems folders being created on the C: drive; in the case of Vista, C:\Users\john.murray\ . From here the O/S will create several folders including "Documents", along with hidden folders containing system, user and application data. I generally will redirect the documents folder to another spindle (drive "D:" in this case). Nearly all applications, including Photoshop, respect this and will look for files in the correct locations. Lightroom does *not*!
hth - John