Lightstand,
You can get very close (though not as precise as with a RIP) printing from with Photoshop, or even InDesign. First and most obvious, make sure your monitor is calibrated. Second, use Photoshop (or InDesign) to control color management. Make sure your correct 2200 print driver is selected from within the print driver menu - i.e. - Epson semi-gloss (250). MAKE SURE ALL COLOR MANAGEMENT IS TURNED OFF IN THE DRIVER.
Under the Photoshop print menu, select Color Management and select "proof" rather than document, IF you have not already converted to CMYK. (I have my system setup for US Sheetfed, rather than Web -- better, and to me, more accurate results.) Under "Color Handling" select "Let Photoshop determine colors", and under Pinter Profile" select your Epson print driver. (A specifically profiled paper is better, but this will work.) Finally, use "Simulate Paper Color". If your image was already CMYK, then you can use "Document" color, but use "Relative Colormetric" and "Black Point Compensation" under "Rendering Intent".
This will get you very close in your proofing. I occasionally do a comparison between my Colorburst RIP and doing it this way for curiosity sake. (I'm working with a 4000.) The results are close -- not matched -- but if you don't have the RIP and don't want to invest in one, this will get you 90-95% of the way there.