I have used DXO on and off, but I find my workflow to be quite slow when I am working with Optics Pro. I am not very happy with the way the software is setup. I am now using Lightroom for raw processing, and I finish off my best shots in LightZone and Photoshop. For images that need optical corrections, I'll be using the DXO Photoshop plug-in. I prefer NeatImage for noise control (over DXO) and I'll also do that with the PS plug-in when required.
One approach that I used to use was to batch correct my Raw images in DXO and output .dng files, which are in a linear RGB colour space (no gamma correction). I would just set DXO to correct optical defects, and noise automatically and make no other changes beyond the Bayer conversion. I was then opening the .dng files with Adobe ACR to set white and black points, exposure, curves etc. You could use this method then import the corrected .dng files into Lightroom. This does cause your Raw images to become 3x the size though, which is why I have decided to just keep DXO for images that really need distortion corrections.
Richard