Hahnemuhle has a Paper Handling Instructions as a PDF that recommends media settings based on what type of Hahnemuhle you are using. If you are using a thick Hahnemuhle stock, and select an Epson Media Selection that is also a thick stock, you are good to go. But if Hahnemuhle suggests using an Epson Media Selection of a paper thinner than what you are printing on, then I suggest going with the Custom Configuration, as the edges of that thick paper may hit the head as it passes over it and give you little black head contact specks on the very edges.
http://www.hahnemuehle.com/site/us/1014/epson.htmlHahnemule recommends Perceptual Rendering Intent with BPC unchecked, but try Rel and BPC checked to see for yourself. They have their 3800 profiles in the same as their 4800 profiles, so try them and see if they are indeed "cross machine" profiles. Hahnemuhle also has Photo Black ink and Matte Black ink profiles for the same art stocks so you can experiment.
For Crane Museo Silver Rag, I have made a Custom Configuration at the printer LCD panel. (doing it there allows you to run an alignment pattern and adjust) I set the gap to wide, the thickness to 5, ran the alignment page, selected 5 as the one that looked perfectly aligned, and left the other adjustments untouched. Then from my desktop, you can remotely access that panel by using the Print Set-up Utility, the selecting LFP Remote Panel, and selecting Media Adjustment, then Activate Custom Paper. You need to press the "Activate" button, not just select it. (This will then give you the same platten gap and thickness as Epson Ultra-Smooth Fine Art paper, I believe). I had to do this because I was using Crane Museo Silver Rag, and but that thick paper requires the thinner Epson Premium Lustre Photo Paper Media Selection (Photo Black ink).