So this is what I am now using as a starting point Preset for 1DsII Low ISO shots.
All zeroed, except:
De Noise 10
ACR Medium Contrast
I also have a high-vibrance Preset, which is the same as above, except Vibrance and Saturation are 30 & 10 respectively.
For Higher ISO (>800), I drop the Sharpening to 25-40 and raise the De-noise to 20.
Interested to know if people are also changing the default boundary lines on the Tone Curve.