I tried this software a few months ago. It sometimes worked very well, and other times became confused and produced garbled images. A new version was recently released which I haven't tried yet. Even when it did work, serious image degradation was apparent at 100%.
So, could be useful when you plan to downsample anyway, otherwise this product has some maturing to do.
Just my opinon.
Sample of a normal image:
Output from Helicon Focus:
That worked well (other than IQ degradation)
Here is another trial which didn;t work:
Look at HF output (see garbled background):
There are several tuning parameters to learn and optimise to avoid these things happening. Also take as many images as possible with minute differences in focus. That should help.