The other thing to remember, is that CCD backs, really don't have a "high ISO" like CMOS, you are just changing the metadata, it's not doing anything on the chip. This is one little issue that have never really been explained in great depth, but CCD MF backs, are really just base ISO, whatever that is anything else is risk you are not changing anything on the chip by increasing ISO. The only thing that really does is Sensor plus, where you get 4:1 and the high ISO is quite acceptable due to the fact that 4x the amount of light has now been used, however at the cost of overall resolution.
Net, if want to push your exposure by increasing the ISO, not exposure the end result will have a lot of noise, i.e 1/30 of a sec at ISO800 vs 1/8 of a sec or 1/4 of a sec at ISO 50.
Exception to this was the IQ260, which does offer a true higher ISO setting for long exposures @ ISO 140, but that back suffers the same as the P65+ much past ISO400, at least mine did. There is NO gain however is use of the long exposure mode LE on the IQ260 to attempt to get a cleaner high ISO, (nothing is gained by using LE mode ISO400, 800 over non LE mode ISO 400/800), believe me I tried to make it work for several years.
Paul Caldwell