I have read posts recommending the use of an anti-static brush or a vacuum cleaner (!?!) on the paper before printing to avoid white defects when dust or paper debris flakes off after the ink is applied. I've had good results simply tapping the edge of sheet paper- even 24x36" sheets- on the desk to dislodge any debris before printing. Wiping down the printer (an Epson 7600) periodically and keeping the paper covered between jobs seems to work for the Epson roll papers I have used.
I suspect that this problem is related to ambient humidity and static. Here in the soggy Northeast, I have only encountered rare flaking in winter when (heated) indoor air gets very dry. This time of year it's a non-issue. It may be worth trying to humidify the air if you live in a dry locale. Just my 2 cents; I don't know if anyone has actually studied this scientifically.