The straightforward information on this appears on LSI's website:
<Note on the Dual Lens System: For transparency mode, the Epson Perfection V850 features two different focus levels. Select scan mode "Transparency", if you want to use a filmholder. In this case, the focus of the scanner optics is precisely adjusted to the film holder. Use scan mode "Wide Transparency" only, if you want to place transparent originals directly on the flatbed. >
Sorry, I mistated: the choice only happens under the hood with SilverFast once you choose the Transparency setting, which is very easy - in the upper left corner of the interface in the dialog for film mode and frame settings, one selects either Transparency or Wide Transparency as recommended above. Then the scanner selects the lens appropriate to that setting.
I tested the difference it makes with four high-res scans - 1800 PPI input, providing an approximate 13*19 inch scanned photo at 300PPI output resolution:
(1) Wide Transparency WITH the FMA (considering it the same as a frame); - wrong combination
(2) Wide Transparency on the Flatbed - correct combination
(3) Transparency WITH the FMA - correct combination
(4) Transparency on the Flatbed - wrong combination
I reduced contrast and increased midtone brightness on this B&W negative of a dark object, so I could see detail very clearly. The photo is of an ebony wood carving, where the fine striations in the wood make a good test of fine detail reproduction. I scanned this 120 sized negative in 16-bit TIFF, so enlarged to 100% in Photoshop the resulting scans would show differences of fine detail rendition. Done this way, one readily sees that using the correct combinations provide better results than using the wrong combinations, as shown in the screen grabs. below, with the image expanded to 100% magnification in Photoshop, no sharpening either at the scan or output stages.
This once again confirms that with this scanner, one may use the flatbed or the FMA and obtain very similar results provided the settings are correct, very easily handled in SilverFast.