While you're waiting for an answer, make a bitmap that is fine patterns of color, like a 1-pixel checkerboard of red and blue pixels, and save with the preview box checked, and look to see where the colors disappear, and you get magenta.
Yes, I know, but I am so lazy today, so I thought I just ask. Anyway, I did it - and got almost blind watching a blue and red checkerboard at 1600%
Color subsampling starts with Photoshop CS2 using
- "Save as" with the slider at 6 or lower
- "Save for Web..." with the slider at 50 or lower (surprise!).