So to be clear, you are asking for user experience about the stability of Lightroom and functionality of profiling and printing with the Sierra version of OSX, right?
If that is what you are looking for, sorry, I haven't upgraded, and won't until the early adopters have helped iron out any bugs in it that affect digital imaging. Normally, however, one should not expect an OS upgrade within the "X" generation to affect monitor profiles or printing work flows. But that statement guarantees nothing.