You could try ColorGATE ProductionServer, which has good automatic and manual nesting capabilities and will drive both Epson and Canon wide-format printers in RGB mode via an OEM module (e.g. EpsonHTM) with standard RGB profiles. I believe it is also capable of profiling and driving these printers as CMYK if necessary, though it's recommended to use RGB for easiest and best results.
If you contact their sales/support people they should be able to arrange a 30-day trial.
I've used ColorGATE now for some 14 years and with various Encad, Epson and Canon printers, so please do ask if you have any specific questions.
Cheers,
Malcolm