If that is the case, the next generation of 135 style mirrorless cameras with a 50 MP Sony back side illuminated CMOS sensor could compete with crop frame medium format cameras. Lenses could be smaller and this is significant, since the lens often dwarfs the mirrorless camera.
On the question of how large a format is needed for "50MP worth" of resolution, meaning about 8000x6000, so 6000 l/ph [lines per picture height] in more traditional measures: I expect lens resolution and diffraction limits on usable f-stops to be the limit. After all, current 1 micron phone-sized pixels would fit about 50MP into a 2/3" format sensor, but the promised resolution would only be achieved at f-stops under about f/2, or f/1 by the most pessimistic analysis, and it might be very hard to control aberrations at those low aperture ratios. (The dynamic range of such small photo-sites is another issue of course, but at least I see hope for techniques like incremental read-out of photo-sites overcoming that.)
Some numbers and speculation:
In 24x16 format ("APS-C", Nikon "DX", Sony "E"), the diffraction limit on resolving that 6000 l/ph is about f/2.8-f/5.6, where maybe aberration control in good modern less designs can handle it.
In 36x24 format, the diffraction limit on resolving that 6000 l/ph is about f/4-f/8, probably within the comfort zone of aberration control in good modern lens designs, including better zoom lenses.
In 44x33 format, it is about f/5.6 - f/11, where it is relatively easy to control aberrations. In fact even 100MP only needs about f/4-f/8, where adequate aberration control is also probably quite attainable.
In the long run, I can see the case for formats bigger than about 44x33 diminishing greatly, if DR at a given pixel size improves as much as I think it can. If so, then Hasselblad is positioning itself well with this new EVF camera system.
P. S. About format names for the larger, more "serious" sensor formats: why not just use dimensions in mm, akin to the use of cm with MF film formats and inches with LF film? It seems that there will be just a few "larger than mainstream" digital ILC formats:
36x24, 44x33 and 54x40 (and at Leica, 45x30).
P.P.S. Do we discuss the X1D in the "Compact System Cameras" forum?!