So far as Switzerlan is concerned, I recommend train rather than car. Driving wastes a lot of time and though possible and spectular to drive, the train provides access that cars do not. You will see from the train but is important to get out in field.
As luxborealis suggested, the Luatternbrunnen valey is wonderful. But you can and should consider it to be the gateway to the Jungfrau region. It is important to hotel right in this region, so that your access does not require an hour train ride, while wasting the best light.
Access to the sights is via cog railroad (e.g Kleine Sheidegg and Jungfrau) or cable car, bus or finicular. Walking can be as strenuous, or not strenuous, as you want. The Swiss walking trails make the US system look like a joke, It is expensive though! You can usually take a lift up to elevation and then walk aroun the mountains on farily level trails, if that is what you want.
Wengen is a nice place to stay,a small village perched above Lautterbrunnen. No cars! You travel from Zurich airport to Interlaken, on to Lauterbrunnen and then by cog railroad to Wengen. Much easier than it sounds, takes 3-4 hours. Once you are there you can take easy walks through the Lauterbrunnen valley. Not to be missed is the walk from Mannlichen to Kleine Scheideg. Monch, Eiger and the Jungfrau tower above this flat walk (elevation about 6000 ft). You will better understand the term Rocky Mountain High after this intoxicating walk. If walking is not your thing, there is the trip to the top of the Jungfrau or the Schilthorn, the villages of Murren and Gimelwald, on and on.
Photography is both rewarding and impossible. Easy because every scene is a postcard. Impossible because everything is a postcard.
I am not sure how to combine with Italy. Perhaps you can continue by train to Italy and then rent a car on arrival. Of course that must be booked in advance. Perhaps others will comment
