I got to wondering about that tonight: what if you use different convertors from time to time. I would imagine each convertor what have to have its own profiles to get the best out of it. Sometimes I'll use Rawshooter for certain images, and the rest of the time its ACR.
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Different raw converters will put out different results but that can be minimized to some extent by disabling sharpening and noise reduction in the converter. Some converters are an exception to that such as Aperture (can create maze patterns) or Raw Shooter Essentials (which there is no clear-cut way of disabling sharpening).
You could use a single set of NN profiles for different converters if the differences noise are small enough. You'll have to test them out yourself for noticeable differences between converters to see if you can get away with using the same profile and have acceptable results.
For the absolute optimum results, you need a separate set of profiles for each converter.