The total size of all the camera and lens profiles is currently 559 Mbyte (or 0.2% of the size of my 256G SSD C drive).
Compare that with the 10G I allow for camera raw cache, or 7G taken by Lightroom previews.
Or the 20G taken by \Windows, including 6G for the Windows component store (\Windows\WinSxS), in which most of the components are rarely if ever used and many are old versions since replaced. Then Program Files and Program Files (x86) take 30G, much of that programs I didn't install and never use. Installers that don't really need to be stored on the disk take another 5G, fonts 400M.
So no, I'm not losing sleep over 0.5G taken by camera and lens profiles, most of which I'll never need.