I have had the 2200, 2400 , the 2880 and now the 3880. I used a CISS on the 2200, 2400 and 2880 with great success . I used the setup from Lyson and Lyson ink. very pleased. The only problem I ran into, other than some clogging, was the waste ink system. After a number of uses the system told me there were parts reaching their service life. basically the waste ink pad etc was almost full. There is software that can overide this and all is good. The crunch comes when the pads are really overloaded and leak out of the printer. To change the pads you have to send the printer to a service depot. usually not economic. I liked the Lyson CISS very much. After the waste ink question on the 2880 i opted to buy a re manufactured 3880 from Epson and have not looked back. No CSS but have got refillable cartridges and use Cone ink which is totally interchangeable with epson so can use all the same profiles etc. VERY PLEASED with the 3880 and Cone inks
Best of luck.
Martin